Ecstasy (MDMA)

MDMA (Methylenedioxymethamphetamine) is a synthetic, psychoactive drug that is chemically similar to the stimulant Methamphetamine and the hallucinogen Mescaline. It produces an energizing effect as well as feelings of euphoria, emotional warmth, and distortions in time perception and tactile experiences.

How is Ecstasy (MDMA) abused?

MDMA is taken orally as a capsule or tablet. It was initially popular among white adolescents and young adults in the nightclub scene or at weekend-long dance parties known as raves. However, the profile of the typical MDMA user has changed, and the drug now affects a broader range of ethnic groups. MDMA is also popular among urban gay males—some report using MDMA as part of a multiple-drug experience that includes MarijuanaCocaineMethamphetamineKetamine, and other legal and illegal substances.

How does Ecstasy (MDMA) affect the brain?

MDMA exerts its primary effects in the brain on neurons that use the chemical serotonin to communicate with other neurons. MDMA binds to the serotonin transporter, which is responsible for removing serotonin from the synapse (or space between adjacent neurons) when the signal between neurons needs to be terminated. MDMA also causes excessive release of serotonin and has similar but less potent effects on neurons that contain dopamine and norepinephrine. The serotonin system plays an important role in regulating mood, aggression, sexual activity, sleep, and sensitivity to pain. MDMA can produce confusion, depression, sleep problems, drug craving, and severe anxiety. These problems can occur soon after taking the drug or, sometimes, even days or weeks after taking MDMA. In addition, chronic users of MDMA perform more poorly than nonusers on certain types of cognitive or memory tasks, although some of these effects may be due to the use of other drugs in combination with MDMA. Research in animals indicates that MDMA can be harmful to the brain.  One study in nonhuman primates showed that exposure to MDMA for only 4 days caused damage to serotonin nerve terminals that was still evident 6 to 7 years later. Although similar neurotoxicity has not been shown definitively in humans, the wealth of animal research indicating MDMA’s damaging properties strongly suggests that MDMA is not a safe drug for human consumption.

This is currently an area of active research. addictive potential For some people, MDMA can be addictive. A survey of young adult and adolescent MDMA users found that 43 percent of those who reported ecstasy use met the accepted diagnostic criteria for dependence, as evidenced by continued use despite knowledge of physical or psychological harm, withdrawal effects, and tolerance (or diminished response). These results are consistent with those of similar studies in other countries that also suggest a high rate of MDMA dependence among users. MDMA abstinence-associated withdrawal symptoms include fatigue, loss of appetite, depressed feelings, and trouble concentrating.

What other adverse effects does Ecstasy (MDMA) have on health?

MDMA can also be dangerous to overall health and, on rare occasions, lethal. MDMA can have many of the same physical effects as other stimulants such as cocaine and amphetamines. These include increases in heart rate and blood pressure, which present risks of particular concern for people with circulatory problems or heart disease; and other symptoms such as muscle tension, involuntary teeth clenching, nausea, blurred vision, faintness, and chills or sweating. In high doses, MDMA can interfere with the body’s ability to regulate temperature. On rare but unpredictable occasions, this can lead to a sharp increase in body temperature (hyperthermia), which can result in liver, kidney, and cardiovascular system failure, and death. MDMA can interfere with its own metabolism (breakdown within the body); therefore, potentially harmful levels can be reached by repeated MDMA administration within short periods of time. Other drugs that are chemically similar to MDMA, such as MDA (Methylenedioxyamphetamine, the parent drug of MDMA) and PMA (Paramethoxyamphetamine, associated with fatalities in the United States and Australia), are sometimes also sold as ecstasy. These drugs can be neurotoxic or create additional health risks to the user. Furthermore, ecstasy tablets may be adulterated with other substances, such as Ephedrine (a stimulant); Dextromethorphan (DXM, a cough suppressant); Ketamine (an anesthetic used mostly by Veterinarians); Caffeine; Cocaine; and Methamphetamine. Although the combination of MDMA with one or more of these drugs may be inherently dangerous, users might also combine these with other substances such as Marijuana and Alcohol, putting themselves at even higher risk.

Source courtesy of: The National Institute on Drug Abuse